Can Language Models Critique Themselves? Investigating Self-Feedback for Retrieval Augmented Generation at BioASQ 2025

Agentic Retrieval Augmented Generation (RAG) and 'deep research' systems aim to enable autonomous search processes where Large Language Models (LLMs) iteratively refine outputs. However, applying these systems to domain-specific professional search, such as biomedical research, presents challenges, as automated systems may reduce user involvement and misalign with expert information needs. Professional search tasks often demand high levels of user expertise and transparency. The BioASQ CLEF 2025 challenge, using expert-formulated questions, can serve as a platform to study these issues. We explored the performance of current reasoning and nonreasoning LLMs like Gemini-Flash 2.0, o3-mini, o4-mini and DeepSeek-R1. A key aspect of our methodology was a self-feedback mechanism where LLMs generated, evaluated, and then refined their outputs for query expansion and for multiple answer types (yes/no, factoid, list, ideal). We investigated whether this iterative self-correction improves performance and if reasoning models are more capable of generating useful feedback. Preliminary results indicate varied performance for the self-feedback strategy across models and tasks. This work offers insights into LLM self-correction and informs future work on comparing the effectiveness of LLM-generated feedback with direct human expert input in these search systems.