Lightweight Data-Free Denoising for Detail-Preserving Biomedical Image Restoration

Current self-supervised denoising techniques achieve impressive results, yet their real-world application is frequently constrained by substantial computational and memory demands, necessitating a compromise between inference speed and reconstruction quality. In this paper, we present an ultra-lightweight model that addresses this challenge, achieving both fast denoising and high quality image restoration. Built upon the Noise2Noise training framework-which removes the reliance on clean reference images or explicit noise modeling-we introduce an innovative multistage denoising pipeline named Noise2Detail (N2D). During inference, this approach disrupts the spatial correlations of noise patterns to produce intermediate smooth structures, which are subsequently refined to recapture fine details directly from the noisy input. Extensive testing reveals that Noise2Detail surpasses existing dataset-free techniques in performance, while requiring only a fraction of the computational resources. This combination of efficiency, low computational cost, and data-free approach make it a valuable tool for biomedical imaging, overcoming the challenges of scarce clean training data-due to rare and complex imaging modalities-while enabling fast inference for practical use.