SpectralAdapt: Semi-Supervised Domain Adaptation with Spectral Priors for Human-Centered Hyperspectral Image Reconstruction

Hyperspectral imaging (HSI) holds great potential for healthcare due to its rich spectral information. However, acquiring HSI data remains costly and technically demanding. Hyperspectral image reconstruction offers a practical solution by recovering HSI data from accessible modalities, such as RGB. While general domain datasets are abundant, the scarcity of human HSI data limits progress in medical applications. To tackle this, we propose SpectralAdapt, a semi-supervised domain adaptation (SSDA) framework that bridges the domain gap between general and human-centered HSI datasets. To fully exploit limited labels and abundant unlabeled data, we enhance spectral reasoning by introducing Spectral Density Masking (SDM), which adaptively masks RGB channels based on their spectral complexity, encouraging recovery of informative regions from complementary cues during consistency training. Furthermore, we introduce Spectral Endmember Representation Alignment (SERA), which derives physically interpretable endmembers from valuable labeled pixels and employs them as domain-invariant anchors to guide unlabeled predictions, with momentum updates ensuring adaptability and stability. These components are seamlessly integrated into SpectralAdapt, a spectral prior-guided framework that effectively mitigates domain shift, spectral degradation, and data scarcity in HSI reconstruction. Experiments on benchmark datasets demonstrate consistent improvements in spectral fidelity, cross-domain generalization, and training stability, highlighting the promise of SSDA as an efficient solution for hyperspectral imaging in healthcare.